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Dear Colleagues,
We want to inform you that we implemented a new improved method for the measurement of patients Nagalase, reported as NAGAnew. It features an improved nagalase measurement differentiating the free nagalase activity, the bound amount of non-active nagalase and the total amount of nagalase (free plus bound). DPP4 value is still provided, and the method remains the same. In addition to the above mentioned set of parameters, a totally new parameter has been developed to get an idea on the response of the innate immune response. Until now nobody has been able to measure free Gc-MAF in serum or plasma. However apart from the cellular capture of Gc-MAF this activating factor is also removed from the blood as a stable complex with the Nagalase enzyme and the amount of this Nagalase-GcMAF complex is an additional parameter to monitor the innate immune defense. The method for determination of Gc-globulin has been changed from turbidimetry towards an ELISA method. The new request forms indicate 2 Nagalase panels: NagaNew1 and NagaNew2.
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